Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome
نویسندگان
چکیده
منابع مشابه
Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome.
BACKGROUND Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trend toward benefit. We conducted two phase 3 studies of a protein-containing surfactant in adults with ARDS. METHODS In two multicenter, randomized, double-blind trials involving 448 patients with AR...
متن کاملTreatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant.
We performed a phase I/II trial in North America of a recombinant surfactant protein C-based surfactant (Venticute) as treatment for the acute respiratory distress syndrome. Patients were prospectively randomized to receive either standard therapy or standard therapy plus one of two doses of exogenous surfactant given four times over 24 hours. Surfactant administration was well tolerated. No si...
متن کاملSurfactant medication for acute respiratory distress syndrome.
Background. Patients with acute respiratory distress syndrome (ARDS) have a deficiency of surfactant. Surfactant replacement improves physiologic function in such patients, and preliminary data suggest that it may improve survival. Methods. We conducted a prospective, multicenter, double-blind, randomized, placebo-controlled trial involving 725 patients with sepsis-induced ARDS. Patients were s...
متن کاملSurfactant treatment for acute respiratory distress syndrome.
OBJECTIVE To determine prospectively the efficacy of surfactant in acute respiratory distress syndrome. STUDY DESIGN Twenty patients, 1 month to 16 years of age, diagnosed with an acute pulmonary disease with severe hypoxaemia (PaO2/FiO2 < 100) (13 with systemic or pulmonary disease and seven with cardiac disease) were treated with one to six doses of 50-200 mg/kg of porcine surfactant admini...
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Pulmonary surfactant is a complex of highly active phospholipids and proteins that cover the alveolar epithelial surface of the lungs [1]. Surfactant is synthesized in the alveolar type-II cells, stored in the lamellar bodies, and secreted to the alveolar space where it undergoes complex changes [2]. The composition of lung surfactant in humans is very constant, although it may change in diseas...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2004
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa033181